久久精品欧美日韩精品,中文字幕av区四区三区二区一区,久久久久久精品免费免费麻辣,欧美日韩免费高清大片

加入收藏 | 設(shè)為首頁(yè) | 聯(lián)系我們

產(chǎn)品搜索

產(chǎn)品分類

聯(lián)系我們

聯(lián)系人:蔣經(jīng)理
電話:4008750250
號(hào)碼:
手機(jī):18066071954
地址:南京市棲霞區(qū)緯地路9號(hào)
Email: zhangxiangwen@cobioer.com

產(chǎn)品展示 / PRODUCTS
藥靶細(xì)胞株 > kinase激酶細(xì)胞株 > CBP73190BCR-ABL1 T315I/BaF3

BCR-ABL1 T315I/BaF3
名稱 BCR-ABL1 T315I/BaF3
型號(hào) CBP73190
報(bào)價(jià)
特點(diǎn) BCR-ABL1 [T315I]/BaF3,母細(xì)胞:BaF3,凍存條件:90% FBS+10% DMSO;
  • 詳細(xì)內(nèi)容
CBP73190
I. Introduction

Cell Line Name:

BCR-ABL1 [T315I]/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative

 
II.Background

Presence of a BCR-ABL1 fusion gene is necessary for the pathogenesis of CML. In up to 95% of cases, a t(9;22) (q34;q11) translocation results in the BCR-ABL1 fusion gene (Faderl et al. 1999). This translocation results in the Philadephia chromosome. In rare CML cases lacking the traditional t(9;22) translocation, other translocations result in the creation of the BCR-ABL1 fusion gene, which sometimes involve multiple chromosomes.
ABL1 is a tyrosine kinase, and, in normal cells, it plays a role in cellular differentiation and regulation of the cell cycle. The BCR-ABL1 fusion gene creates a constitutively active tyrosine kinase, which leads to uncontrolled proliferation.
Imatinib is the first-generation ABL tyrosine kinase inhibitor, and it was approved by the FDA in 2001; label indications for CML include use in newly diagnosed adult and pediatric patients and in patients after failure of interferon-alpha therapy. While treatment responses to imatinib are often dramatic and lasting, 30–40% of patients will eventually need further treatment (Santos et al. 2011). In many but not all cases, this is due to the acquisition of point mutations in the tyrosine kinase domain of the BCR-ABL1 fusion gene, which renders the protein insensitive to the inhibitory effect of imatinib. This type of disease progression led to the development of second-line TKIs: dasatinib, nilotinib, and bosutinib. Dasatinib and bosutinib have the additional advantage of being inhibitors of SRC.
The second-generation TKIs, dasatinib, nilotinib, and bosutinib, are more potent than imatinib, and they were developed to treat cases of CML resistant to imatinib. Dasatinib and nilotinib are approved for use in CML in newly diagnosed adults, while dasatinib, nilotinib, and bosutinib are approved for use in adults with resistance or intolerance to prior therapy that included imatinib (FDA 2012). Soverini et al. (2011) made mutation-specific treatment decision recommendations that were adopted by NCCN (2012). Recommendations based on preclinical data are as follows: for T315I, HSCT or clinical trial; for V299L, T315A, and F317L/V/I/C, consider nilotinib rather than dasatinib; for Y253H, E255K/V, and F359V/C/I, consider dasatinib rather than nilotinib; and for all other mutations, consider high-dose imatinib, dasatinib, or nilotinib.
Ponatinib is a third-line TKI, developed specifically to address imatinib resistance due to the BCR-ABL1 T315I resistance mutation. Ponatinib is currently being investigated in phase III clinical trials.

 
III. Representative Data

1. WB of BCR-ABL1 [T315I]/BaF3


2. Sanger of BCR-ABL1 [T315I]/BaF3


Figure 2. BCR-ABL1 T315I/BaF3 T315I

Figure 3. BCR-ABL1 T315I/BaF3 Fusion

 

3. Anti-proliferation assay

Figure 4. CTG Proliferation Assay of BaF3 BCR-ABL1 T315I Cells.

如果你對(duì)CBP73190BCR-ABL1 T315I/BaF3感興趣,想了解更詳細(xì)的產(chǎn)品信息,填寫(xiě)下表直接與廠家聯(lián)系:


留言框

  • 產(chǎn)品:

  • 您的單位:

  • 您的姓名:

  • 聯(lián)系電話:

  • 常用郵箱:

  • 省份:

  • 詳細(xì)地址:

  • 補(bǔ)充說(shuō)明:

  • 驗(yàn)證碼:

    請(qǐng)輸入計(jì)算結(jié)果(填寫(xiě)阿拉伯?dāng)?shù)字),如:三加四=7

化工儀器網(wǎng)

推薦收藏該企業(yè)網(wǎng)站
丁香婷婷亚洲六月综合色| 国产精品毛片一区视频播| 操你的骚逼粉嫩AV| 女人逼逼出水视频| 久久久精品日韩一区二区三区| 婷婷6月天丁香综合在线| 亚洲av伦理一区二区三区久久| 蜜臀AV无码国产精品尤物| 女教师色色天天免费播放| 鸡巴操骚逼视频播放| 久久亚洲精品中文字幕一| 国产日韩一区二区三区在线播放| 日本 视频 一区二区| 色999日韩自偷自拍美女| 午夜国产三级一区二区三| 黄色日女人逼视频| 天天免费的无码AV| 国产精品视频一区二区三区分享| 操女人真人大骚逼| 欧美国产日韩a欧美在线| 午夜国产三级一区二区三| 男人几把操女人嫩穴| 狠狠色伊人亚洲综合成人| 小美女淫荡的视频| 日韩美女叉B视频| 欧美 日韩 国产 自拍| 骚逼被操视频拳交| 免费女人男人肏逼| 一区二区三区四区五六区| 大鸡巴操大屁股美女视频| 国产亚洲一区二区手机在线观看| 91麻豆精品福利在线观看| 日韩一区二区三区国色天香| 久久婷婷综合五月一区二区| 日本高清不卡一区二区三区| 成年人的一级黄色带| 欧美大鸡巴操穴日韩| 欧美日韩亚洲人人夜夜澡| 久久精品国产亚洲高清| 国产精品免费久久久久久| 国产A级黄片下载|