名稱 | FLT3-ITD D835del/BaF3 |
型號(hào) | CBP73241 |
報(bào)價(jià) | |
特點(diǎn) | FLT3-ITD [D835del]/BaF3,母細(xì)胞:BaF3,凍存條件:90% FBS+10% DMSO |
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藥靶細(xì)胞株 > kinase激酶細(xì)胞株 > CBP73241FLT3-ITD D835del/BaF3
- 詳細(xì)內(nèi)容
CBP73241 | |
I. Introduction | |
Cell Line Name: | FLT3-ITD [D835del]/BaF3 |
Host Cell: | Ba/F3 |
Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS+2ug/ml puromycin |
Mycoplasma Status: | Negative |
II.Background | |
FLT3, receptor-type tyrosine-protein kinase FLT3, activates Akt, Ras, and Erk pathways to regulate differentiation, proliferation, and survival of hematopoietic progenitor cells (PMID: 29316714, PMID: 28538663). Activating mutations of FLT3 are common in hematologic tumors (PMID: 19467916) and the internal tandem duplication (ITD) mutation is commonly observed in acute myeloid leukemia (PMID: 30181385). | |
III. Representative Data | |
1.FLT3-ITD [D835del]/BaF3 | |
2. Anti-proliferation assay | |
Figure . Anti-proliferation assay of three reference compounds on the FLT3-ITD [D835del]/BaF3 Stable Cell Line. |